izindaba

Njengamanje, i-magnetic resonance imaging (MRI) iyathuthuka isuka ekufanekisweni kwesakhiwo sendabuko kanye nokuthwebula okusebenzayo kuye ekufanekisweni kwamangqamuzana. I-Multi-nuclear MR Ingathola ulwazi oluhlukahlukene lwe-metabolite emzimbeni womuntu, kuyilapho igcina ukulungiswa kwendawo, ithuthukise ukucaciswa kokutholwa kwezinqubo ze-physiological kanye ne-pathological, futhi okwamanje iwukuphela kobuchwepheshe obungakwazi ukuhlaziya okungenakuvinjelwa kwe-quantitative ye-human dynamic molecule metabolism in vivo.

Ngokujula kwe-multi-core MR Research, inamathemba abanzi okusebenza ekuhlolweni kokuqala nasekuxilongweni kwezicubu, izifo zenhliziyo, izifo ze-neurodeergenerative, uhlelo lwe-endocrine, uhlelo lokugaya ukudla kanye nezifo zesistimu yokuphefumula, kanye nokuhlolwa okusheshayo kwenqubo yokwelashwa. Inkundla yakamuva kaPhilips yocwaningo lwemitholampilo ehlukahlukene izosiza ukuthwebula izithombe kanye nodokotela basemtholampilo benze ucwaningo lwezempilo olusezingeni eliphezulu. UDkt. Sun Peng kanye noDkt. Wang Jiazheng abavela eMnyangweni Wokusekela Umtholampilo Nobuchwepheshe base-Philips banikeze isingeniso esiningiliziwe sokuthuthukiswa kwe-multi-NMR kanye nesiqondiso socwaningo se-Philips' new multi-core MR Platform.

I-Magnetic resonance iwine uMklomelo kaNobel izikhathi ezinhlanu emlandweni wayo, emikhakheni yonkana ye-physics, chemistry, biology, kanye nezokwelapha, futhi izuze impumelelo enkulu ezimisweni eziyisisekelo zefiziksi, ukwakheka kwamangqamuzana ezinto eziphilayo, amandla e-biological macromolecular structure, kanye ne-imaging medical medical. Phakathi kwazo, i-imaging magnetic resonance ingenye yezobuchwepheshe obubaluleke kakhulu be-imaging yezokwelapha, esetshenziswa kabanzi ekuxilongweni kwezifo ezihlukahlukene ezingxenyeni ezihlukahlukene zomzimba womuntu. Ngokuthuthukiswa okuqhubekayo kwezidingo zokunakekelwa kwezempilo, isidingo esikhulu sokuxilongwa kusenesikhathi kanye nokuhlolwa kokuphumelela okusheshayo sikhuthaza ukuthuthukiswa kwe-imaging magnetic resonance kusukela ku-imaging yesakhiwo sendabuko (T1w, T2w, PDw, njll.), imaging esebenzayo (DWI, PWI, njll.) kuya ku-imaging yamangqamuzana (1H MRS Kanye ne-multi-core MRS/MRI).

Ingemuva eliyinkimbinkimbi ye-1H esekelwe ku-MR Technology, i-spectra egqagqene, kanye nokuminyanisa kwamanzi/amafutha kukhawulela isikhala sawo njengobuchwepheshe bokuthwebula be-molecular. Inani elilinganiselwe lama-molecule (i-choline, i-creatine, i-NAA, njll.) lingatholwa, futhi kunzima ukuthola izinqubo ze-metabolic zamangqamuzana ashukumisayo. Ngokusekelwe ezinhlobonhlobo zama-nuclide (23Na, 31P, 13C, 129Xe, 17O, 7Li, 19F, 3H, 2H), multi-nuclear MR Ingathola ulwazi oluhlukahlukene lwe-metabolite lomzimba womuntu, ngokulungiswa okuphezulu nokucaciswa okuphezulu, futhi okwamanje ukuphela kwe-non-invasive, i-stable metabolite ye-isolitestope e-stable; (i-glucose, ama-amino acid, ama-fatty acids - angenabuthi) ukuze kuhlaziywe inani lezinqubo ze-metabolic zamangqamuzana ashukumisayo.

Ngokuthuthuka okuqhubekayo ohlelweni lwe-hardware ye-magnetic resonance, indlela yokulandelana okusheshayo (I-Multi-Band, i-Spiral) kanye ne-algorithm yokusheshisa (inzwa ecindezelweyo, ukufunda okujulile), i-multi-core MR Imaging/spectroscopy ivuthwa kancane kancane: (1) kulindeleke ukuthi ibe ithuluzi elibalulekile lokusika-onqenqemeni lwebhayoloji yamangqamuzana, i-biochemistry kanye nocwaningo lwe-metabolism yomuntu; (2) Njengoba isuka ocwaningweni lwesayensi iye ekusebenzeni komtholampilo (inani lezilingo zomtholampilo ezisekelwe ku-MR ye-multi-core Iyaqhubeka, FIG. 1), inamathemba abanzi ekuhlolweni kokuqala kanye nokuxilongwa komdlavuza, izifo zenhliziyo, i-neurodegenerative, izifo zokugaya ukudla kanye nokuphefumula, kanye nokuhlola ukusebenza kahle ngokushesha.

Ngenxa yezimiso zomzimba eziyinkimbinkimbi nobunzima obuphezulu bezobuchwepheshe be-MR Field, i-multi-core MR Ibe yindawo yocwaningo eyingqayizivele yezikhungo ezimbalwa eziphezulu zocwaningo lobunjiniyela. Nakuba i-multicore MR Enze inqubekelaphambili ebalulekile ngemva kwamashumi eminyaka entuthuko, kusenokuntuleka kwedatha eyanele yomtholampilo yokuqhubekisela phambili lo mkhakha ukuze usize ngempela iziguli.

Ngokusekelwe emisha eqhubekayo emkhakheni we-MR, u-Philips wagcina ephule ibhodlela lentuthuko ye-multi-core MR Futhi wakhipha inkundla entsha yocwaningo lomtholampilo enama-nuclide amaningi embonini. Inkundla iwukuphela kwesistimu enezinto eziningi emhlabeni zokuthola isitifiketi se-EU Safety Conformity Certification (CE) kanye nesitifiketi se-US Food and Drug Administration (FDA), esivumela Isixazululo se-MR esinezitaki eziningi esigcwele umkhiqizo: amakhoyili agunyazwe yi-FDA, ukumbozwa okugcwele kokulandelana, kanye nokwakhiwa kabusha okujwayelekile kwesiteshi somsebenzisi. Abasebenzisi abadingi ukuhlonyiswa ngongoti besayensi ye-resonance kazibuthe, onjiniyela bekhodi nabaklami be-RF gradient, okulula kune-spectroscopy/imaging evamile ye-1H. Khulisa ukuncishiswa kwezindleko zokusebenza ze-MR eziyisisekelo eziningi, ukushintsha kwamahhala phakathi kocwaningo lwesayensi kanye nemodi yomtholampilo, ukutholwa kwezindleko ezisheshayo, ukuze uMR we-multi-core MR Ngempela angene emtholampilo.

I-Multi-core MR manje isiyisiqondiso esibalulekile “soHlelo Lokuthuthukiswa Kwemboni Yezisetshenziswa Zezokwelapha Yeminyaka Ye-14”, futhi iwubuchwepheshe obuyisihluthulelo bokwenza izithombe zezokwelapha zidlule esimisweni futhi zihlanganiswe ne-biomedicine esezingeni eliphezulu. Ithimba lososayensi base-Philips China, eliqhutshwa ukuthuthukisa ucwaningo lwesayensi yamakhasimende kanye nekhono lokusungula, lenze ucwaningo oluhlelekile ngo-MR onama-multi-core. UDkt. Sun Peng, uDkt. Wang Jiazheng et al. okokuqala kwahlongoza umqondo we-MR-nucleomics ku-NMR ku-Biomedicine (i-top Journal of the First Region of Spectroscopy of Chinese Academy of Sciences), engasebenzisa i-MR Ngokusekelwe kuma-nuclide ahlukene ukuze ibone imisebenzi eyahlukahlukene yamaseli nezinqubo ze-pathological. Ngakho-ke, ukwahlulela okuphelele nokuhlolwa kwezifo nokwelashwa kungenziwa [1]. Umqondo we-MR Multinucleomics uzoba umhlahlandlela wesikhathi esizayo we-MR Development. Leli phepha liwukubuyekezwa kokuqala okuhlelekile kwe-multi-core MR Emhlabeni, okuhlanganisa isisekelo sethiyori se-multi-core MR, ucwaningo lwangaphambi komtholampilo, ukuguqulwa komtholampilo, ukuthuthukiswa kwe-hardware, ukuqhubeka kwe-algorithm, umkhuba wobunjiniyela nezinye izici (Umfanekiso 2). Ngesikhathi esifanayo, ithimba lososayensi labambisana noProfesa Song Bin weSibhedlela sase-West China ukuze baqedele isihloko sokuqala sokubuyekezwa mayelana nokuguqulwa komtholampilo kwe-multi-core MR E-China, eyanyatheliswa kumagazini i-Insights into Imaging [2]. Ukushicilelwa kochungechunge lwezihloko ezikhuluma nge-multicore MR Kubonisa ukuthi i-Philips iletha ngempela umngcele we-multicore imaging yamangqamuzana e-China, kumakhasimende aseShayina, kanye nasezigulini zaseShayina. Ngokuhambisana nomqondo oyinhloko othi "e-China, e-China", i-Philips izosebenzisa i-multi-core MR Ukukhuthaza ukuthuthukiswa kwe-resonance magnetic yase-China nokusiza imbangela ye-China enempilo.

I-Multi-nuclear MRI ubuchwepheshe obusafufusa. Ngokuthuthukiswa kwe-MR Software kanye ne-hardware, i-MRI enezinuzi eziningi iye yasetshenziswa ocwaningweni oluyisisekelo nolwezempilo lokuhumusha lwezinhlelo zabantu. Inzuzo yayo eyingqayizivele ukuthi ingabonisa izinqubo ze-metabolic zesikhathi sangempela eziguquguqukayo ezinqubweni ezihlukene ze-pathological, ngaleyo ndlela inikeze amathuba okuxilongwa kusenesikhathi kwezifo, ukuhlolwa kokuphumelela, ukwenza izinqumo zokwelashwa kanye nokuthuthukiswa kwezidakamizwa. Kungase kusize ngisho nokuhlola izindlela ezintsha ze-pathogenesis.

Ukuze kuthuthukiswe ukuthuthukiswa okuqhubekayo kwalo mkhakha, ukubamba iqhaza okusebenzayo kochwepheshe bezokwelapha kuyadingeka. Ukuthuthukiswa komtholampilo kwamapulatifomu amaningi kubalulekile, okuhlanganisa ukwakhiwa kwezinhlelo eziyisisekelo, ukumiswa kobuchwepheshe, ukulinganisa kanye nokumiswa kwemiphumela, ukuhlola ama-probes amasha, ukuhlanganiswa kolwazi oluningi lwe-metabolic, njll., ngaphezu kokuthuthukiswa kwezivivinyo ezingase zibe khona ezindaweni eziningi, ukuze kuqhutshekwe kuthuthukiswe ukuguqulwa komtholampilo kwe-MR Technology ethuthukisiwe. Sikholelwa ngokuqinile ukuthi i-MR ye-multi-core izohlinzeka ngesiteji esibanzi sochwepheshe bezithombe kanye nochwepheshe bezokwelapha ukuze benze ucwaningo lwezokwelapha, futhi imiphumela yakhona izozuzisa iziguli emhlabeni jikelele.