Muva nje, isihloko sephephabhuku laseGunma University School of Medicine eJapane sibike ukuthi isibhedlela sabangela i-cyanosis ezinsaneni eziningi ezisanda kuzalwa ngenxa yokungcoliswa kwamanzi kampompi. Lolu cwaningo lusikisela ukuthi ngisho namanzi ahlungiwe angangcoliswa kungaqondile nokuthi izingane zingase zibe ne-methemoglobinemia.
Ukuqubuka kwe-Methemoglobinemia e-ICU Yezingane Ezisanda kuzalwa kanye neWadi Yokubeletha
Izingane ezisanda kuzalwa eziyishumi egunjini labagula kakhulu kanye nasewodini yababeletha bathola i-methemoglobinemia ngenxa yokuphakelwa ifomula elakhiwe ngamanzi kampompi angcolile. Ukugxila kwe-Methemoglobin kusuka ku-9.9% kuya ku-43.3%. Iziguli ezintathu zithole i-methylene eluhlaza okwesibhakabhaka (umcibisholo), ebuyisela amandla okuthwala umoya-mpilo we-hemoglobin, futhi ngemva kwamahora ayisishiyagalolunye, zonke iziguli eziyi-10 zabuyela kokujwayelekile ngokwesilinganiso. Umfanekiso B ubonisa umdwebo we-valve eyonakele kanye nomsebenzi wayo ovamile. Umfanekiso C ukhombisa ubudlelwano phakathi kwamanzi okuphuza kanye nepayipi lokufudumeza. Amanzi okuphuza esibhedlela aphuma emthonjeni futhi adlula ohlelweni lokuhlanza kanye nesisefo esibulala amagciwane. Umzila wokujikeleza wokushisa uhlukaniswa nokunikezwa kwamanzi okuphuza nge-valve yokuhlola. Ukwehluleka kwe-valve yokuhlola kubangela ukuthi amanzi ageleze abuyele emugqeni wokujikeleza wokushisa aye emgqeni wokuphakela amanzi okuphuza.
Ukuhlaziywa kwamanzi ompompi kubonise okuqukethwe okuphezulu kwe-nitrite. Ngemva kophenyo olwengeziwe, sinqume ukuthi amanzi okuphuza ayengcolile ngenxa yokungasebenzi kwe-valve okubangelwa ukugeleza emuva kwesistimu yokushisisa yasesibhedlela. Amanzi ohlelweni lokushisisa aqukethe izinto ezilondolozayo (Izibalo 1B kanye no-1C). Nakuba amanzi okumpompi asetshenziswa ekwenziweni kobisi lwezinsana enziwe amagciwane ngezihlungi ukuze ahlangabezane nezindinganiso zikazwelonke, izihlungi azikwazi ukuqeda ama-nitrites. Eqinisweni, amanzi kampompi kuso sonke isibhedlela ayengcolile, kodwa asikho nesisodwa isiguli esikhulile esathola i-methemoglobin.
Uma kuqhathaniswa nezingane ezindala kanye nabantu abadala, izinsana ezingaphansi kwezinyanga ezimbili zisengozini enkulu yokuba ne-methemoglobinosis ngoba izinsana ziphuza amanzi amaningi ngekhilogremu ngayinye yesisindo somzimba futhi zinomsebenzi ophansi we-NADH cytochrome b5 reductase, oguqula i-methemoglobin ibe i-hemoglobin. Ukwengeza, i-pH ephakeme esiswini sosana isiza ukuba khona kwamagciwane anciphisa i-nitrate emgudwini wokugaya ongaphezulu, oguqula i-nitrate ibe yi-nitrite.
Leli cala libonisa ukuthi ngisho nalapho ifomula lilungiswa kusetshenziswa amanzi ahlungwe kahle, i-methemoglobin ingabangelwa ukungcoliswa kwamanzi okungahlosiwe. Ngaphezu kwalokho, leli cala liqokomisa iqiniso lokuthi izinsana zingenwa kalula yi-methemoglobin kunabantu abadala. Ukuqaphela lezi zici kubalulekile ekuhlonzeni umthombo we-methemoglobin kanye nokunciphisa izinga lokuqubuka kwayo.
Isikhathi sokuthumela: Mar-09-2024